| Sudomotor Dysfunction in patients with D.M. is caused by Small Fibre Neuropathy and contributes to Diabetic Foot Pathology and increased risk of foot ulceration. Diabetic Patients with abnormal neuropad test result have higher risk of foot ulceration. Abnormal neuropad test results correlate with ulceration at foot of Diabetes patients. This study includes 379 Diabetes Mellitus patients. Patients with foot ulceration had more various peripheral neuropathy and higher incidence for abnormal neuropad test. The multivariate statistical analysis shows that Diabetes Mellitus patients with abnormal neuropad test result are16 times more likely to develop foot ulceration compared to those with a normal neuropad test result. Sudomotor dysfunction diagnosis with neuropad test provides an earlier diagnosis of Diabetic Neuropathy. The invariably lower specificity than sensitivity is due to the fact that neuropad® is abnormal in about one third of patients with clinical examination negative for neuropathy. It has been proposed that this result may be ascribed to earlier diagnosis of neuropathy by means of neuropad® before conventional clinical signs become positive. N.Papanas, D.Ziegler: New diagnostic tests for diabetic distal symmetric polyneuropathy. J Diabetes Complications. 2011 Jan-Feb;25(1):44-51. neuropad test positive result in Diabetic Patients without Clinical Neuropathy is a remarkable indicator for the development of Clinical Neuropathy in the future. This appears to reflect early Small Fibre Involvement which is missed using NDS as a measure of Neuropathy.
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Homeopathy & Veterinarian
